Endocrine Abstracts

A 66-year-old woman had no history of systemic diseases. She had developed watery diarrhea for 4 months initially, without abdominal pain, fever, any aggravating or relieving factor. She visited gastroenterologist, and colonoscopy showed only mixed hemorrhoid. Irritable bowel syndrome was impressed then. Thus, anti-spasmodics and anti-diarrheals were prescribed. However, diarrhea persisted for 1 year, and body weight loss of 7 kg occurred during this period of time. She later ...

Abundant evidence demonstrates that long-term cytokine-mediated inflammation is a risk factor for obesity and type 2 diabetes mellitus (T2DM). Our previous study shows a significant association between IL4 genotypes and T2DM, as well as between IL4 genotypes and the lower circulatory levels of high-density lipoprotein-cholesterol (HDL-C). In addition, IL4 has anti-hyperglycemic function by improving insulin sensitivity and glucose tolerance as well as being involved in lipid m...